| Full text | |
| Author(s): Show less - |
Machado, Rafael R. G.
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Walker, Jordyn L.
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Scharton, Dionna
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Rafael, Grace H.
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Mitchell, Brooke M.
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Reyna, Rachel A.
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de Souza, William M.
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Liu, Jianying
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Walker, David H.
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Plante, Jessica A.
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Plante, Kenneth S.
;
Weaver, Scott C.
Total Authors: 12
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| Document type: | Journal article |
| Source: | NATURE COMMUNICATIONS; v. 14, n. 1, p. 13-pg., 2023-07-17. |
| Abstract | |
The SARS-CoV-2 Omicron subvariant BA.5 rapidly spread worldwide and replaced BA.1/BA.2 in many countries, becoming globally dominant. BA.5 has unique amino acid substitutions in the spike protein that both mediate immune escape from neutralizing antibodies produced by immunizations and increase ACE2 receptor binding affinity. In a comprehensive, long-term (up to 9 months post primary vaccination), experimental vaccination study using male Syrian hamsters, we evaluate neutralizing antibody responses and efficacy against BA.5 challenge after primary vaccination with Ad26.COV2.S (Janssen) or BNT162b2 (Pfizer/BioNTech) followed by a homologous or heterologous booster with mRNA-1273 (Moderna) or NVX-CoV2373 (Novavax). Notably, one high or low dose of Ad26.COV2.S provides more durable immunity than two primary doses of BNT162b2, and the NVX-CoV2373 booster provides the strongest augmentation of immunity, reduction in BA.5 viral replication, and disease. Our data demonstrate the immunogenicity and efficacy of different prime/boost vaccine regimens against BA.5 infection in an immune-competent model and provide new insights regarding COVID-19 vaccine strategies. Long-term BA.5-specific efficiency of booster vaccination is incompletely understood. Here, analyzing immunity to and efficacy of various COVID-19 vaccination regimens in Syrian hamster, the authors found that heterologous boosting provides more durable immunity and that NVX-CoV2373 provides the strongest boosting effect. (AU) | |
| FAPESP's process: | 19/27803-2 - Immune-mediated mayaro virus protection from wild-type chikungunya virus infection |
| Grantee: | Rafael Rahal Guaragna Machado |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |