Folic acid-conjugated curcumin-loaded bioMOF-101 for breast cancer therapy

Author(s)

Alves, Renata Carolina ; Quijia, Christian Rafael ; da Silva, Patricia Bento ; Faria, Raquel Santos ; Cabral Morais, Amanda Alencar ; Lopes de Araujo, Henrique Loback ; de Azevedo, Ricardo Bentes ; Chorilli, Marlus

• Document type: Journal article
• Source: JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY; v. 86, p. 11-pg., 2023-07-06.

Abstract

Breast cancer ranks as the primary cause of cancer-related mortality among women and stands as the fifth leading cause of cancer death overall. Biocompatible metal-organic frameworks (bioMOFs) emerge as highly attractive and promising platforms for efficient drug absorption and delivery. Thus, our objective was to develop drug delivery systems using bioMOF-101 materials, incorporating curcumin (CCM). The materials were enhanced by coating with folate molecules, facilitating targeted delivery to the tumor region. BioMOF-101 was meticulously synthesized, characterized using various techniques, and subsequently subjected to drug encapsulation tests. Remarkably, CCM@bioMOF-101-1D achieved an impressive encapsulation efficiency of 99.42%. To evaluate the impact of the MOF on cell viability, both breast tumor and normal cell lines were examined, revealing that the materials exhibited no toxicity. In vivo studies, bio-MOFs did not induce a reduction in the tumor region; however, the CCM@bioMOF-101-1D/FA caused a reduction in alveolar volume, which is indicative of its effectiveness in the model employed. In conclusion, the matrices studied herein can be considered promising alternatives for the treatment of breast cancer. (AU)

• FAPESP's process: 17/26065-2 - Encapsulation of curcumin in BioMOF-100 functionalized with folate: development and evaluation of potential in the treatment of Breast Cancer
• Grantee: Renata Carolina Alves
• Support Opportunities: Scholarships in Brazil - Doctorate