| Full text | |
| Author(s): |
Braga, Deisi L.
;
Mousovich-Neto, Felippe
;
Tonon-da-Silva, Guilherme
;
Salgueiro, Willian G.
;
Mori, Marcelo A.
Total Authors: 5
|
| Document type: | Journal article |
| Source: | BIOGERONTOLOGY; v. 21, n. 4, p. 21-pg., 2020-04-30. |
| Abstract | |
As life expectancy increases worldwide, ageing and age-related diseases arise as a major issue for societies around the globe. Understanding the biological mechanisms underlying the ageing process is thus instrumental for the development of efficient interventions aimed to prevent and treat age-related conditions. Current knowledge in the biogerontology field points to epigenetics as a critical component of the ageing process, not only by serving as a bona-fide marker of biological age but also by controlling and conferring inheritability to cellular and organismal ageing. This is reflected by a myriad of evidences demonstrating the relationship between DNA methylation, histone modifications, chromatin remodeling and small non-coding RNAs and several age-related phenotypes. Given the reversibility of epigenetic alterations, epigenetic reprogramming may also be envisioned as a potential approach to treat age-related disorders. Here we review how different types of epigenetic mechanisms are involved in the ageing process. In addition, we highlight how interventions modulate epigenetics and thus promote health- and lifespan. (AU) | |
| FAPESP's process: | 19/14391-8 - Screening and characterization of Dicer regulators in C. elegans |
| Grantee: | Willian Goulart Salgueiro |
| Support Opportunities: | Scholarships abroad - Research Internship - Master's degree |
| FAPESP's process: | 17/22057-5 - Physiological effects and transgenerational inheritance induced by cholesterol-rich diet in Caenorhabditis elegans |
| Grantee: | Willian Goulart Salgueiro |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 17/08829-5 - Investigation of the interaction between Dicer and the NAD+ signalling pathway in C. elegans metabolism and aging |
| Grantee: | Guilherme Tonon da Silva |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 18/11672-3 - Characterization in mice of novel genes involved in the evolutionarily conserved mechanisms of dietary restriction and its mimetics |
| Grantee: | Felippe Mousovich Neto |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/01184-9 - CAMeLEOm: cross-species analysis of metabolic, lifespan effects and omics of dietary restriction mimetics |
| Grantee: | Marcelo Alves da Silva Mori |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 18/11792-9 - Characterization in C. elegans of novel genes involved in aging and the evolutionarily conserved mechanisms of dietary restriction mimetics |
| Grantee: | Deisi Lilian Braga Shimo |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |