Effect of coronaviruses on blood vessel permeability: potential therapeutic targets

Author(s)

Machado, Nicolle R. ; Dias, Karina T. ; Cortes, Bryan F. S. ; Rodrigues, Stephen F.

• Document type: Journal article
• Source: THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE; v. 17, p. 20-pg., 2023-01-01.

Abstract

Coronavirus-induced diseases have afflicted humanity for several decades. This scenario was aggravated by the emergence of the coronavirus disease 2019 (named COVID-19) in Wuhan, China, in December 2019. Since then, COVID-19 has killed millions of people worldwide, probably the most devastating pandemic since HIV/AIDS. This review aimed to bring together important updated aspects related to coronavirus-induced diseases and the enhanced vascular permeability observed mainly in the lungs of affected people. The dysregulated vascular permeability in the lungs is of fundamental importance for coronaviruses-caused morbidity and mortality. Thus, as described in this review, it is a target of new and old drugs. (AU)

• FAPESP's process: 20/07212-7 - Effect of doxycycline, secretory leukocyte protease inhibitor (SLPI), inhaled aldosterone or gold nanoparticles treatment in a murine model of acute respiratory distress syndrome
• Grantee: Stephen Fernandes de Paula Rodrigues
• Support Opportunities: Regular Research Grants
• FAPESP's process: 20/16756-0 - Effect of sepsis severity on the leukocyte adhesion in pial blood vessels, locomotor activity and depressive-like behavior in mice
• Grantee: Bryan Fellipe da Silva Cortes
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• FAPESP's process: 20/12616-0 - Effect of aging and hypertension on the sperm quality and testis microcirculation of rats
• Grantee: Nicolle Rakanidis Machado
• Support Opportunities: Scholarships in Brazil - Scientific Initiation