Prospecting Local Treatments Used in Conjunction with Antivenom Administration Following Envenomation Caused by Animals: A Systematic Review

Author(s):Show less -

Carvalho, Erica S. ; Oliveira, Isadora ; Nascimento, Thais P. ; Neto, Alexandre Vilhena da Silva ; Leal, Brenda A. S. ; Araujo, Felipe Q. ; Juliao, Bruno F. V. ; Souza, Andrea R. N. ; Abrahim, Andreza W. ; Macedo, Bruna B. O. ; de Oliveira, Jessica T. S. ; Wen, Fan Hui ; Pucca, Manuela B. ; Monteiro, Wuelton M. ; Sachett, Jacqueline A. G.

• Document type: Journal article
• Source: TOXINS; v. 15, n. 5, p. 19-pg., 2023-04-28.

Abstract

Envenomation caused by venomous animals may trigger significant local complications such as pain, edema, localized hemorrhage, and tissue necrosis, in addition to complications such as dermonecrosis, myonecrosis, and even amputations. This systematic review aims to evaluate scientific evidence on therapies used to target local effects caused by envenomation. The PubMed, MEDLINE, and LILACS databases were used to perform a literature search on the topic. The review was based on studies that cited procedures performed on local injuries following envenomation with the aim of being an adjuvant therapeutic strategy. The literature regarding local treatments used following envenomation reports the use of several alternative methods and/or therapies. The venomous animals found in the search were snakes (82.05%), insects (2.56%), spiders (2.56%), scorpions (2.56%), and others (jellyfish, centipede, sea urchin-10.26%). In regard to the treatments, the use of tourniquets, corticosteroids, antihistamines, and cryotherapy is questionable, as well as the use of plants and oils. Low-intensity lasers stand out as a possible therapeutic tool for these injuries. Local complications can progress to serious conditions and may result in physical disabilities and sequelae. This study compiled information on adjuvant therapeutic measures and underscores the importance of more robust scientific evidence for recommendations that act on local effects together with the antivenom. (AU)

• FAPESP's process: 20/13176-3 - Human monoclonal antibodies (scFv) discovery with cross-reactivity and pH-dependent to metalloproteases from Bothrops spp
• Grantee: Isadora Sousa de Oliveira
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 22/08964-8 - Discovery of human monoclonal antibodies (scFv) with cross-reactivity and pH-dependent targeting metalloprotease from Bothrops spp.
• Grantee: Isadora Sousa de Oliveira
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor