New Palladium(II) Complexes Containing Methyl Gallate and Octyl Gallate: Effect against Mycobacterium tuberculosis and Campylobacter jejuni

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Silva, Raphael Tristao Cruvinel ; Guidotti-Takeuchi, Micaela ; Peixoto, Jessica Laura Miranda ; Demarqui, Fernanda Manaia ; Mori, Ananda Paula ; Dumont, Carolyne Ferreira ; Ferreira, Gabriella Rayane Aparecida ; Pereira, Gabriele de Menezes ; Rossi, Daise Aparecida ; Corbi, Pedro Paulo ; Pavan, Fernando Rogerio ; Rezende Junior, Celso de Oliveira ; de Melo, Roberta Torres ; Guerra, Wendell

• Document type: Journal article
• Source: Molecules; v. 28, n. 9, p. 16-pg., 2023-05-05.

Abstract

This work describes the preparation, characterization and antimicrobial activity of four palladium(II) complexes, namely, [Pd(meg)(1,10-phen)] 1, [Pd(meg)(PPh3)(2)] 2, [Pd(og)(1,10-phen)] 3 and [Pd(og)(PPh3)(2)] 4, where meg = methyl gallate, og = octyl gallate, 1,10-phen = 1,10-phenanthroline and PPh3 = triphenylphosphine. As to the chemical structures, spectral and physicochemical studies of 1-4 indicated that methyl or octyl gallate coordinates a palladium(II) ion through two oxygen atoms upon deprotonation. A chelating bidentate phenanthroline or two triphenylphosphine molecules complete the coordination sphere of palladium(II) ion, depending on the complex. The metal complexes were tested against the Mycobacterium tuberculosis H37Rv strain and 2 exhibited high activity (MIC = 3.28 mu g/mL). As to the tests with Campylobacter jejuni, complex 1 showed a significant effect in reducing bacterial population (greater than 7 log CFU) in planktonic forms, as well as in the biomass intensity (IBF: 0.87) when compared to peracetic acid (IBF: 1.11) at a concentration of 400 mu g/mL. The effect provided by these complexes has specificity according to the target microorganism and represent a promising alternative for the control of microorganisms of public health importance. (AU)

• FAPESP's process: 21/08717-8 - Synthesis of copper, silver and gold complexes involving nucleotide analogues in the search of new alternatives for the treatment of ovarian cancer
• Grantee: Pedro Paulo Corbi
• Support Opportunities: Regular Research Grants