| Full text | |
| Author(s): |
Freitas, Mateus Silveira
;
Bitencourt, Tamires Aparecida
;
Rezende, Caroline Patini
;
Martins, Nubia Sabrina
;
Dourado, Thales de Mileto Henrique
;
Tirapelli, Carlos R.
;
Almeida, Fausto
Total Authors: 7
|
| Document type: | Journal article |
| Source: | JOURNAL OF FUNGI; v. 9, n. 5, p. 15-pg., 2023-05-04. |
| Abstract | |
Fungal extracellular vesicles (EVs) mediate intra- and interspecies communication and are critical in host-fungus interaction, modulating inflammation and immune responses. In this study, we evaluated the in vitro pro- and anti-inflammatory properties of Aspergillus fumigatus EVs over innate leukocytes. A. fumigatus EVs induced a partial proinflammatory response by macrophages, characterized by increased tumor necrosis factor-alpha production, and increased gene expression of induced nitric oxide synthase and adhesion molecules. EVs induce neither NETosis in human neutrophils nor cytokine secretion by peripheral mononuclear cells. However, prior inoculation of A. fumigatus EVs in Galleria mellonella larvae resulted in increased survival after the fungal challenge. Taken together, these findings show that A. fumigatus EVs play a role in protection against fungal infection, although they induce a partial pro-inflammatory response. (AU) | |
| FAPESP's process: | 21/06794-5 - Fungal extracellular vesicles: immunomodulation and cellular communication |
| Grantee: | Fausto Bruno dos Reis Almeida |
| Support Opportunities: | Research Grants - Young Investigators Grants - Phase 2 |
| FAPESP's process: | 19/22454-0 - Evaluation of the immunomodulatory potential of extracellular vesicles produced by Aspergillus fumigatus |
| Grantee: | Mateus Silveira Freitas |
| Support Opportunities: | Scholarships in Brazil - Doctorate |