| Full text | |
| Author(s): |
Araujo, Layanne C. C.
;
Cruz, Alessandra G.
;
Camargo, Felipe N.
;
Sucupira, Felipe G.
;
Moreira, Gabriela V.
;
Matos, Sandro L.
;
Amaral, Andressa G.
;
Murata, Gilson Masahiro
;
Carvalho, Carla R. O.
;
Camporez, Joao Paulo
Total Authors: 10
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 24, n. 12, p. 15-pg., 2023-06-01. |
| Abstract | |
The prevalence of non-alcoholic fatty liver disease (NAFLD) and its severe form, non-alcoholic steatohepatitis (NASH), is higher in men than in women of reproductive age, and postmenopausal women are especially susceptible to developing the disease. Aim: we evaluated if female apolipoprotein E (ApoE) KO mice were protected against Western-diet (WD)-induced NASH. Methods: Female ovariectomized (OVX) ApoE KO mice or sham-operated (SHAM) mice were fed either a WD or a regular chow (RC) for 7 weeks. Additionally, OVX mice fed a WD were treated with either estradiol (OVX + E2) or vehicle (OVX). Results: Whole-body fat, plasma glucose, and plasma insulin were increased and associated with increased glucose intolerance in OVX mice fed a WD (OVX + WD). Plasma and hepatic triglycerides, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) hepatic enzymes were also increased in the plasma of OVX + WD group, which was associated with hepatic fibrosis and inflammation. Estradiol replacement in OVX mice reduced body weight, body fat, glycemia, and plasma insulin associated with reduced glucose intolerance. Treatment also reduced hepatic triglycerides, ALT, AST, hepatic fibrosis, and inflammation in OVX mice. Conclusions: These data support the hypothesis that estradiol protects OVX ApoE KO mice from NASH and glucose intolerance. (AU) | |
| FAPESP's process: | 19/18965-9 - Effect of increased estrogen receptor alpha expression by adeno-associated virus on hepatic metabolism |
| Grantee: | Felipe Nunes de Camargo |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |
| FAPESP's process: | 18/04956-5 - Impact of the estrogen receptor alpha on Non-Alcoholic Fatty Liver Disease and energetic metabolism of the liver |
| Grantee: | João Paulo Gabriel Camporez |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 20/09094-1 - Impact of galectin-3 inhibition on hepatic insulin resistance and energy metabolism in Non-Alcoholic Steato-Hepatitis |
| Grantee: | Layanne Cabral da Cunha Araujo |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 21/02638-9 - Impact of estrogen receptor alpha on non-alcoholic fatty liver disease and liver energy metabolism |
| Grantee: | Felipe Garcia da Silva Sucupira |
| Support Opportunities: | Scholarships in Brazil - Master |