| Full text | |
| Author(s): |
Contessoto, Vinicius G.
;
Dudchenko, Olga
;
Aiden, Erez Lieberman
;
Wolynes, Peter G.
;
Onuchic, Jose N.
;
Di Pierro, Michele
Total Authors: 6
|
| Document type: | Journal article |
| Source: | NATURE COMMUNICATIONS; v. 14, n. 1, p. 12-pg., 2023-01-19. |
| Abstract | |
We use data-driven physical simulations to study the three-dimensional architecture of the Aedes aegypti genome. Hi-C maps exhibit both a broad diagonal and compartmentalization with telomeres and centromeres clustering together. Physical modeling reveals that these observations correspond to an ensemble of 3D chromosomal structures that are folded over and partially condensed. Clustering of the centromeres and telomeres near the nuclear lamina appears to be a necessary condition for the formation of the observed structures. Further analysis of the mechanical properties of the genome reveals that the chromosomes of Aedes aegypti, by virtue of their atypical structural organization, are highly sensitive to the deformation of the nuclei. This last finding provides a possible physical mechanism linking mechanical cues to gene regulation. (AU) | |
| FAPESP's process: | 16/13998-8 - Rational evolution by computational methods applied to predict mutations in enzymes to biofuels production |
| Grantee: | Vinícius de Godoi Contessoto |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 17/09662-7 - Rational Evolution by Computational Methods Applied in Enzymes Related to Bioethanol Production |
| Grantee: | Vinícius de Godoi Contessoto |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |