| Full text | |
| Author(s): |
Sanabria, Viviam
;
Romariz, Simone
;
Braga, Matheus
;
Foresti, Maira Licia
;
Naffah-Mazzacoratti, Maria da Graca
;
Mello, Luiz Eugenio
;
Longo, Beatriz M. M.
Total Authors: 7
|
| Document type: | Journal article |
| Source: | FRONTIERS IN NEUROSCIENCE; v. 16, p. 8-pg., 2023-02-24. |
| Abstract | |
Interest in the use of anticholinergics to prevent the development of epilepsy after traumatic brain injury (TBI) has grown since recent basic studies have shown their effectiveness in modifying the epileptogenic process. These studies demonstrated that treatment with anticholinergics, in the acute phase after brain injury, decreases seizure frequency, and severity, and the number of spontaneous recurrent seizures (SRS). Therefore, anticholinergics may reduce the risk of developing posttraumatic epilepsy (PTE). In this brief review, we summarize the role of the cholinergic system in epilepsy and the key findings from using anticholinergic drugs to prevent PTE in animal models and new clinical trial protocols. Furthermore, we discuss why treatment with anticholinergics is more likely to prevent PTE than treatment for other epilepsies. (AU) | |
| FAPESP's process: | 17/05242-3 - STUDY OF THE ANTICONVULSANT EFFECT OF CANNABIDIOL AFTER TRAUMATIC BRAIN INJURY. |
| Grantee: | Simone Amaro Alves Romariz Bertola |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 18/24561-5 - Epileptogenesis, biomarkers and post-traumatic epilepsy |
| Grantee: | Luiz Eugenio Araujo de Moraes Mello |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 22/10520-0 - Post-traumatic Epilepsy model induced by lateral fluid percussion in non-human primates |
| Grantee: | Viviam Sofia Sanabria Calvo |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |