Mechanochemical method: a powerful tool to obtain omega-poly(ethylene glycol)-functionalized structures and curcumin analogues

Author(s)

de Moura, Aniele ; Gaglieri, Caroline ; Terciotti, Luiz Octavio ; Rinaldo, Daniel ; Caires, Flavio Junior

• Document type: Journal article
• Source: NEW JOURNAL OF CHEMISTRY; v. 47, n. 19, p. 9-pg., 2023-04-18.

Abstract

This work reports the mechanochemical synthesis of organic compounds involving carbon-carbon (C-C), carbon-nitrogen (C-N), and carbon-oxygen (C-O). The solid-state synthesis of omega-poly(ethylene glycols) functionalized with different cyclic anhydrides and the obtainment of curcumin Schiff bases and curcumin multicomponent derivatives are also reported. The mechanochemical method was also used in the Steglich esterification using curcumin derivatives. H-1 NMR, C-13 NMR, MIR, XRPD, and HPLC techniques were performed to confirm the synthesis of each compound. (AU)

• FAPESP's process: 18/24378-6 - Synthesis, characterization and thermoanalytical study of Valsartan, Candesartan Cilexetil and Olmesartan medoxomil co-crystals
• Grantee: Flávio Junior Caires
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/07296-2 - CDMF - Center for the Development of Functional Materials
• Grantee: Elson Longo da Silva
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC