| Full text | |
| Author(s): |
Dos Santos, Benedito M.
;
Przyborski, Jude M.
;
Garcia, Celia R. S.
Total Authors: 3
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 24, n. 8, p. 11-pg., 2023-04-01. |
| Abstract | |
During their life cycle, apicomplexan parasites pass through different microenvironments and encounter a range of ion concentrations. The discovery that the GPCR-like SR25 in Plasmodium falciparum is activated by a shift in potassium concentration indicates that the parasite can take advantage of its development by sensing different ionic concentrations in the external milieu. This pathway involves the activation of phospholipase C and an increase in cytosolic calcium. In the present report, we summarize the information available in the literature regarding the role of potassium ions during parasite development. A deeper understanding of the mechanisms that allow the parasite to cope with ionic potassium changes contributes to our knowledge about the cell cycle of Plasmodium spp. (AU) | |
| FAPESP's process: | 17/08684-7 - Decoding Plasmodium signaling at molecular level as a new tool to the development of new antimalarials |
| Grantee: | Célia Regina da Silva Garcia |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 20/08988-9 - Evaluation of compounds with antimalarial potential and study of the signal transduction mechanism of GPCR (G-Protein Coupled Receptor) like PfSR25 in Plasmodium falciparum |
| Grantee: | Benedito Matheus dos Santos |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |