The Omicron Lineages BA.1 and BA.2 (Betacoronavirus SARS-CoV-2) Have Repeatedly Entered Brazil through a Single Dispersal Hub

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Lamarca, Alessandra P. P. ; de Souza, Ueric Jose Borges ; Moreira, Filipe Romero Rebello ; de Almeida, Luiz G. P. ; de Menezes, Mariane Talon ; de Souza, Adrieli Barboza ; Ferreira, Alessandro Clayton de Souza ; Gerber, Alexandra L. ; de Lima, Aline B. ; Guimaraes, Ana Paula de C. ; Cavalcanti, Andrea Cony ; Paz e Silva, Aryel B. ; Lima, Bruna Israel ; Lobato, Cirley ; Da Silva, Cristiane Gomes ; Mendonca, Cristiane P. T. B. ; Queiroz, Daniel Costa ; Zauli, Danielle Alves Gomes ; Menezes, Diego ; Possebon, Fabio Sossai ; Cardoso, Franciano Dias Pereira ; Malta, Frederico Scott Varella ; Braga-Paz, Isabela ; Silva, Joice do Prado ; Ferreira, Jorge Gomes Goulart ; Galvao, Jucimaria Dantas ; de Souza, Leandro Magalhaes ; Ferreira, Leonardo ; Possuelo, Lia Goncalves ; Cavalcante, Liliane Tavares de Faria ; Alvim, Luige B. ; de Souza, Luiz Fellype Alves ; de Araujo E Santos, Luiza C. G. ; Dias, Rillery Calixto ; Souza, Rutilene Barbosa ; Regina y Castro, Thais ; Valim, Andreia Rosane de Moura ; Campos, Fabricio Souza ; Araujo Jr, Joao Pessoa ; Trindade, Priscila de Arruda ; Aguiar, Renato S. S. ; Delai, Robson Michael ; de Vasconcelos, Ana Tereza R.

• Document type: Journal article
• Source: Viruses-Basel; v. 15, n. 4, p. 13-pg., 2023-04-01.

Abstract

Brazil currently ranks second in absolute deaths by COVID-19, even though most of its population has completed the vaccination protocol. With the introduction of Omicron in late 2021, the number of COVID-19 cases soared once again in the country. We investigated in this work how lineages BA.1 and BA.2 entered and spread in the country by sequencing 2173 new SARS-CoV-2 genomes collected between October 2021 and April 2022 and analyzing them in addition to more than 18,000 publicly available sequences with phylodynamic methods. We registered that Omicron was present in Brazil as early as 16 November 2021 and by January 2022 was already more than 99% of samples. More importantly, we detected that Omicron has been mostly imported through the state of Sao Paulo, which in turn dispersed the lineages to other states and regions of Brazil. This knowledge can be used to implement more efficient non-pharmaceutical interventions against the introduction of new SARS-CoV variants focused on surveillance of airports and ground transportation. (AU)

• FAPESP's process: 19/18581-6 - Development of colorimetric kits for quantification of porcine circoviruses 2 (PCV-2) and SARS-CoV2 using gold nanoparticles
• Grantee: João Pessoa Araújo Junior
• Support Opportunities: Regular Research Grants