| Author(s): |
Celes, M. R. N.
;
Torres-Duenas, D.
;
Campos, E. C.
;
Prado, C. M.
;
Cunha, F. Q.
;
Rossi, M. A.
;
Kimchi, A
Total Authors: 7
|
| Document type: | Journal article |
| Source: | CURRENT ADVANCES IN HEART DISEASE; v. N/A, p. 2-pg., 2008-01-01. |
| Abstract | |
Impairment of myocardial contractility in severe sepsis/septic shock in the absence of preload and afterload has been recognized as an important factor that contributes to the high mortality in critically-ill patients Evidence from our laboratory indicates that myocardial structural changes could be responsible for sepsis-induced myocardial dysfunction. This study was tests the hypotheses that alterations in Intercellular communication and mechanical coupling between neighboring cardiomyocytes and in dystrophin-glycoprotein complex (DGC) could occur in severe experimental sepsis and contribute to myocardial depression. Male C57BI/6 mice were subjected to moderate (MSI) or severe (SSI) septic injury induced by cecal ligation and puncture (CLP). Our results showed a decreased expression of gap (connexin43) and adherens junction (N-cadherin) proteins with remodeling of the intercalated disc in severe sepsis. In addition, there was a decreased expression of major proteins, dystrophin and beta-dystroglican, implicated in the mechanical binding between the entire arrays of myofibrils to the extracellular matrix. It is our interpretation that these changes could contribute to myocardial depression in sepsis. (AU) | |
| FAPESP's process: | 07/58843-2 - O possivel papel do calcio no mecanismo intrinseco de perda primaria de distrofina na patogenese da disfuncao cardiaca na sepsis experimental. |
| Grantee: | Mara Rúbia Nunes Celes |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 06/59618-0 - O possível papel do complexo de glicoproteínas associadas à distrofia na morte súbita na tripanossomiase americana experimental |
| Grantee: | Marcos Antonio Rossi |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 06/52882-3 - O possível papel do complexo de glicoproteínas associadas à distrofina na morte súbita na tripanosomíase americana experimental |
| Grantee: | Cibele Maria Prado Zinni |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |