| Full text | |
| Author(s): |
Cardoso Filho, Cassio
;
Lourenco, Gustavo
;
Shinzato, Julia Yoriko
;
Zeferino, Luiz Carlos
;
Costa, Fernando Ferreira
;
Passos Lima, Carmen Silvia
;
Costa Gurgel, Maria Salete
Total Authors: 7
|
| Document type: | Journal article |
| Source: | ONCOLOGY REVIEWS; v. 2, n. 1, p. 8-pg., 2008-01-01. |
| Abstract | |
There is a lack of consensus about the influence of GST M1/T1 gene deletions (DEL) on sporadic breast cancer (SBC). To evaluate the occurrence of DEL in 177 SBC cases and in 169 controls, and compare clinical and biological characteristics. A lower frequency of GSTM1 DEL was observed in mulatto women, OR=0.48 (0.24-0.98). The risk of nuclear grade 3 tumors (GN3) was lower in patients with GSTT1 DEL, OR=0.37 (0.15-0.90). DEL of at least one gene (ALOG) was associated with women who had not breastfed, OR=0.41 (0.19-0.88), and with negative hormone receptor, HR-, ORadj=2.25 (1.03-4.90). Both genes deleted (BGD) was associated with non-classic invasive ductal carcinoma (NCDC), ORadj=12.09 (1.03-142.03). Mulatto women with SBC had a lower frequency of GSTM1 DEL, while tumors differentiated were related to GSTT1 DEL. HR-tumors were related with DEL ALOG, and the BGD was associated with a greater risk of NCDC. (AU) | |