Projections From the Anterior Interposed Nucleus to the Red Nucleus Diminish With Age in the Mouse

Author(s)

Olyntho-Tokunaga, H. H. V. ; Pinto, M. L. ; Souccar, C. ; Schoorlemmer, G. H. M. ; Lapa, R. C. R. S.

• Document type: Journal article
• Source: ANATOMIA HISTOLOGIA EMBRYOLOGIA; v. 37, n. 6, p. 4-pg., 2008-12-01.

Abstract

To analyse the effect of ageing on the projection of the anterior interposed nucleus to the red nucleus, we injected the retrograde tracer fluorogold in the red nucleus of 3-, 6- and 12-month-old mice. The number of labelled neurones in the anterior interposed nucleus fell by 9% between 3 and 6 months and by another 9% between 6 and 12 months (all P < 0.001). This suggests that loss of neurones from the cerebellar nuclei starts well before old age. (AU)