Preparation of clavulanate salt using a tertiary octylamine as an intermediate

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Author(s):	Hirata, D. Battaglia ; Hortolan Luiz de Oliveira, J. H. ; Ferreira, A. G. ; Leao, K. Veloso ; Sousa, C. P. ; Barboza, M. ; Hokka, C. Osamu ; MendezVilas, A Total Authors: 8
Document type:	Journal article
Source:	CURRENT RESEARCH TOPICS IN APPLIED MICROBIOLOGY AND MICROBIAL BIOTECHNOLOGY; v. N/A, p. 2-pg., 2009-01-01.
Abstract
This paper describes a study of the preparation of an organic ammonium salt of clavulanic acid by a precipitation reaction. The choice of clavulanic acid was based on its significance for the pharmaceutical industry and on the fact that the precipitation of this organic compound has been little Studied and is, unlike inorganic compounds, complex. The objective was to Study the influence of the initial concentration of clavulanic acid on the precipitation reaction with a tertiary octylamine. The extraction of clavulanic acid was performed at temperatures less than 20 degrees C and, preferably, near 15 degrees C in the water-immiscible organic solvents ethyl acetate. The drying step was performed with a suitable desiccant. Thus, an insoluble salt with clavulanic acid was formed. The precipitate obtained was crystalline, stable and was analyzed by H-1 NMR. (AU)

FAPESP's process:	05/55079-4 - Production and purification of clavulanic acid, cephamycin C and other bioactive metabolites of Streptomyces
Grantee:	Carlos Osamu Hokka
Support Opportunities:	Research Projects - Thematic Grants