| Full text | |
| Author(s): Show less - |
Regasini, Luis Octavio
;
Castro-Gamboa, Ian
;
Siqueira Silva, Dulce Helena
;
Furlan, Maysa
;
Barreiro, Eliezer Jesus
;
Pinheiro Ferreira, Paulo Michel
;
Pessoa, Claudia
;
Costa Lotufo, Leticia Veras
;
de Moraes, Manoel Odorico
;
Marx Young, Maria Claudia
;
Bolzani, Vanderlan da Silva
Total Authors: 11
|
| Document type: | Journal article |
| Source: | Journal of Natural Products; v. 72, n. 3, p. 4-pg., 2009-03-01. |
| Abstract | |
As part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of I and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells. (AU) | |
| FAPESP's process: | 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II |
| Grantee: | Vanderlan da Silva Bolzani |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |