Optimization of the continuous clavulanic acid adsorption process

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Author(s):	Almeida, Renata M. R. G. ; Pasotto, Marlei B. ; Hokka, Carlos O. ; MendezVilas, A Total Authors: 4
Document type:	Journal article
Source:	MICROORGANISMS IN INDUSTRY AND ENVIRONMENT: FROM SCIENTIFIC AND INDUSTRIAL RESEARCH TO CONSUMER PRODUCTS; v. N/A, p. 6-pg., 2011-01-01.
Abstract
This paper proposes an optimization of the variables involved in the continuous adsorption process of clavulanic acid (CA) on an ion exchange resin, using a complete factorial design. A continuous adsorption run was done to validate the factors that maximized the process yield. A comparison of the yield, concentration factor and purification factor values obtained in the simulated and experimental runs indicated a difference of less than 11%. (AU)

FAPESP's process:	05/55079-4 - Production and purification of clavulanic acid, cephamycin C and other bioactive metabolites of Streptomyces
Grantee:	Carlos Osamu Hokka
Support Opportunities:	Research Projects - Thematic Grants