| Full text | |
| Author(s): |
Zimbres, Flavia M.
;
Tarnok, Attila
;
Ulrich, Henning
;
Wrenger, Carsten
Total Authors: 4
|
| Document type: | Journal article |
| Source: | BIOMED RESEARCH INTERNATIONAL; v. 2013, p. 7-pg., 2013-01-01. |
| Abstract | |
Worldwide the entire human population is at risk of infectious diseases of which a high degree is caused by pathogenic protozoans, worms, bacteria, and virus infections. Moreover the current medications against pathogenic agents are losing their efficacy due to increasing and even further spreading drug resistance. Therefore, there is an urgent need to discover novel diagnostic as well as therapeutic tools against infectious agents. In view of that, the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) represents a powerful technology to target selectively pathogenic factors as well as entire bacteria or viruses. SELEX uses a large combinatorial oligonucleic acid library (DNA or RNA) which is processed a by high-flux in vitro screen of iterative cycles. The selected ligands, termed aptamers, are characterized by high specificity and affinity to their target molecule, which are already exploited in diagnostic and therapeutic applications. In this minireview we will discuss the current status of the SELEX technique applied on bacterial and viral pathogens. (AU) | |
| FAPESP's process: | 11/19703-6 - Identification and interference with nutrient transporters integrated to erythrocyte surface by the Human Malaria parasite: Plasmodium falciparum |
| Grantee: | Flávia Menezes Zimbres |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 10/20647-0 - Elucidation of vitamin B metabolism in the human malaria parasite plasmodium falciparum and their validation as a target for chemotherapy |
| Grantee: | Carsten Wrenger |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 12/50393-6 - Aptamers for diagnostic marker and therapeutic inhibitor discovery in infectious diseases |
| Grantee: | Alexander Henning Ulrich |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/54325-2 - Elucidation of vitamin B metabolism in the human malaria parasite Plasmodium falciparum and their validation as a target for chemotherapy |
| Grantee: | Carsten Wrenger |
| Support Opportunities: | Research Grants - Young Investigators Grants |