| Full text | |
| Author(s): |
Twardowschy, Andre
;
Castiblanco-Urbina, Maria Angelica
;
Uribe-Marino, Andres
;
Biagioni, Audrey Francisco
;
Salgado-Rohner, Carlos Jose
;
de Souza Crippa, Jose Alexandre
;
Coimbra, Norberto Cysne
Total Authors: 7
|
| Document type: | Journal article |
| Source: | JOURNAL OF PSYCHOPHARMACOLOGY; v. 27, n. 12, p. 11-pg., 2013-12-01. |
| Abstract | |
The potential anxiolytic and antipanic properties of cannabidiol have been shown; however, its mechanism of action seems to recruit other receptors than those involved in the endocannabinoid-mediated system. It was recently shown that the model of panic-like behaviors elicited by the encounters between mice and snakes is a good tool to investigate innate fear-related responses, and cannabidiol causes a panicolytic-like effect in this model. The aim of the present study was to investigate the 5-hydroxytryptamine (5-HT) co-participation in the panicolytic-like effects of cannabidiol on the innate fear-related behaviors evoked by a prey versus predator interaction-based paradigm. Male Swiss mice were treated with intraperitoneal (i.p.) administrations of cannabidiol (3 mg/kg, i.p.) and its vehicle and the effects of the peripheral pre-treatment with increasing doses of the 5-HT1A receptor antagonist WAY-100635 (0.1, 0.3 and 0.9 mg/kg, i.p.) on instinctive fear-induced responses evoked by the presence of a wild snake were evaluated. The present results showed that the panicolytic-like effects of cannabidiol were blocked by the pre-treatment with WAY-100635 at different doses. These findings demonstrate that cannabidiol modulates the defensive behaviors evoked by the presence of threatening stimuli, and the effects of cannabidiol are at least partially dependent on the recruitment of 5-HT1A receptors. (AU) | |
| FAPESP's process: | 09/01157-5 - Study of the involvement of the opioid system and the neural networks between medial hypothalamus and periaqueductal grey matter in antinociceptive processes induced by oriented escaped reactions evoked after chemical stimulation of the medial hypothalamus |
| Grantee: | Maria Angelica Castiblanco Urbina |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 09/01153-0 - Involvement of locus coeruleus neural pathways and noradrenergic neurotransmission in the dorsal raphe nucleus in antinociceptive processes induced by oriented escape reactions evoked by chemical stimulation of the medial hypothalamus |
| Grantee: | Andres Uribe Marino |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 08/00531-8 - Study of the interaction between Opioid and GABAergic mechanisms in the Dorsal Mesencephalon and its Role in the Modulation of Defensive Behaviour Organized in the Inferior Colliculus and Periaqueductal Grey Matter |
| Grantee: | Andre Twardowschy |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 08/08955-1 - Involvement of the Dorsal Raphe Nucleus Neural Networks and Serotonergic Neurotransmittion in the Locus Coeruleus in Antinociceptive Processess Induced by Oriented Escape Reaction Evoked by Chemical Stimulation of the Medial Hypothalamus. |
| Grantee: | Audrey Franceschi Biagioni |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 10/15140-4 - Neuropharmacological study of the involvement of dorsal rafe nucleus and serotoninergic systems in the antinociceptive process induced by oriented escape reaction evoked by GABAergic disinhibition of the dorsomedial hypothalamus |
| Grantee: | Audrey Franceschi Biagioni |
| Support Opportunities: | Scholarships in Brazil - Doctorate |