Structural characterization of vitamin B1 and B6 synthesis pathway enzymes in Plas...
EMU 2015/26722-8 AVANTI J-30 I Biosafe centrifuge including rotor
| Full text | |
| Author(s): |
Kronenberger, Thales
;
Lindner, Jasmin
;
Meissner, Kamila A.
;
Zimbres, Flavia M.
;
Coronado, Monika A.
;
Sauer, Frank M.
;
Schettert, Isolmar
;
Wrenger, Carsten
Total Authors: 8
|
| Document type: | Journal article |
| Source: | BIOMED RESEARCH INTERNATIONAL; v. 2014, p. 11-pg., 2014-01-01. |
| Abstract | |
Malaria is a deadly infectious disease which affects millions of people each year in tropical regions. There is no effective vaccine available and the treatment is based on drugs which are currently facing an emergence of drug resistance and in this sense the search for new drug targets is indispensable. It is well established that vitamin biosynthetic pathways, such as the vitamin B6 de novo synthesis present in Plasmodium, are excellent drug targets. The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in the malaria parasite which includes the ornithine decarboxylase (ODC, synthesis of polyamines), the aspartate aminotransferase (AspAT, involved in the protein biosynthesis), and the serine hydroxymethyltransferase (SHMT, a key enzyme within the folate metabolism). (AU) | |
| FAPESP's process: | 13/10288-1 - Analysis of the organelle biogenesis in Plasmodium falciparum by live cell imaging |
| Grantee: | Carsten Wrenger |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 10/20647-0 - Elucidation of vitamin B metabolism in the human malaria parasite plasmodium falciparum and their validation as a target for chemotherapy |
| Grantee: | Carsten Wrenger |
| Support Opportunities: | Scholarships in Brazil - Young Researchers |
| FAPESP's process: | 12/12790-3 - Analysis of the haemoglobin catabolism of Plasmodium falciparum proliferation in genetically modified erythrocytes |
| Grantee: | Jasmin Lindner |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 09/54325-2 - Elucidation of vitamin B metabolism in the human malaria parasite Plasmodium falciparum and their validation as a target for chemotherapy |
| Grantee: | Carsten Wrenger |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 11/13706-3 - Implications from pyridoxine kinase of Plasmodium falciparum and study if its spacer regions |
| Grantee: | Thales Kronenberger |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/12807-3 - Analysis of the redox status and its effect on the proliferation of Plasmodium falciparum in genetically different erythrocytes |
| Grantee: | Kamila Anna Meissner |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 11/19703-6 - Identification and interference with nutrient transporters integrated to erythrocyte surface by the Human Malaria parasite: Plasmodium falciparum |
| Grantee: | Flávia Menezes Zimbres |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |