| Full text | |
| Author(s): |
Xavier-Neto, Jose
;
Sousa Costa, Angela M.
;
Figueira, Ana Carolina M.
;
Caiaffa, Carlo Donato
;
do Amaral, Fabio Neves
;
Cerqueira Peres, Lara Maldanis
;
Pires da Silva, Barbara Santos
;
Santos, Luana Nunes
;
Moise, Alexander R.
;
Castilo, Hozana Andrade
Total Authors: 10
|
| Document type: | Journal article |
| Source: | BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS; v. 1849, n. 2, p. 18-pg., 2015-02-01. |
| Abstract | |
Retinoic acid (RA) is a terpenoid that is synthesized from vitamin A/retinol (ROL) and binds to the nuclear receptors retinoic acid receptor (RAR)/retinoid X receptor (RXR) to control multiple developmental processes in vertebrates. The available clinical and experimental data provide uncontested evidence for the pleiotropic roles of RA signaling in development of multiple embryonic structures and organs such eyes, central nervous system, gonads, lungs and heart. The development of any of these above-mentioned embryonic organ systems can be effectively utilized to showcase the many strategies utilized by RA signaling. However, it is very likely that the strategies employed to transfer RA signals during cardiac development comprise the majority of the relevant and sophisticated ways through which retinoid signals can be conveyed in a complex biological system. Here, we provide the reader with arguments indicating that RA signaling is exquisitely regulated according to specific phases of cardiac development and that RA signaling itself is one of the major regulators of the timing of cardiac morphogenesis and differentiation. We will focus on the role of signaling by RA receptors (RARs) in early phases of heart development. This article is part of a Special Issue entitled: Nuclear receptors in animal development (C) 2014 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 11/15273-7 - The role of nuclear receptors in the atrial specification |
| Grantee: | Bárbara Santos Pires da Silva |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 13/12008-6 - Studies of structure and function of aldehyde dehydrogenases involved in cellular signaling pathways and detoxification |
| Grantee: | Fábio Neves do Amaral |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 12/14859-0 - Study on the molecular mechanisms of the orphan nuclear receptor COUP-TFII action during cardiac chambers development |
| Grantee: | Carlo Donato Simões Caiaffa Feliciano de Carvalho |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |