Neonatal Sepsis and Inflammatory Mediators

Author(s)

Machado, Juliana Reis ; Soave, Danilo Figueiredo ; da Silva, Marcos Vinicius ; de Menezes, Liliana Borges ; Etchebehere, Renata Margarida ; Goncalves dos Reis Monteiro, Maria Luiza ; dos Reis, Marlene Antonia ; Miranda Correa, Rosana Rosa ; Nunes Celes, Mara Rubia

• Document type: Journal article
• Source: Mediators of Inflammation; v. 2014, p. 10-pg., 2014-01-01.

Abstract

Neonatal sepsis is a major cause of morbidity and mortality and its signs and symptoms are nonspecific, which makes the diagnosis difficult. The routinely used laboratory tests are not effective methods of analysis, as they are extremely nonspecific and often cause inappropriate use of antibiotics. Sepsis is the result of an infection associated with a systemic inflammatory response with production and release of a wide range of inflammatory mediators. Cytokines are potent inflammatory mediators and their serum levels are increased during infections, so changes from other inflammatory effector molecules may occur. Although proinflammatory and anti-inflammatory cytokines have been identified as probable markers of neonatal infection, in order to characterize the inflammatory response during sepsis, it is necessary to analyze a panel of cytokines and not only the measurement of individual cytokines. Measurements of inflammatory mediators bring new options for diagnosing and following up neonatal sepsis, thus enabling early treatment and, as a result, increased neonatal survival. By taking into account the magnitude of neonatal sepsis, the aim of this review is to address the role of cytokines in the pathogenesis of neonatal sepsis and its value as a diagnostic criterion. (AU)

• FAPESP's process: 11/23220-0 - Role of the phosphoinositide-3-kinase/serin-treonin kinase (PI3K/AKT) signaling pathway in the expression of dystrophin in the myocardium of animals submitted to cecal ligation and puncture (CLP).
• Grantee: Erica Carolina Campos Pulici
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 11/08234-5 - Experimental septic cardiomyopathy mimicking the common clinical scenario (two-hit model): cecal ligation and puncture followed by Pseudomonas aeruginosa-induced pneumonia
• Grantee: Maria José Figueiredo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 11/18427-5 - Influence of hypoxia on CD44/CD24 adhesion molecules expression in biopsies and cell lines of benign and malignant salivary gland neoplasm.
• Grantee: Danilo Figueiredo Soave
• Support Opportunities: Scholarships in Brazil - Doctorate