B-1 phagocytes: the myeloid face of B-1 cells

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Author(s):	Popi, Ana Flavia ; Ghosn, E ; Rothstein, TL ; Herzenberg, LA ; Holodick, NE Total Authors: 5
Document type:	Journal article
Source:	B-1 CELL DEVELOPMENT AND FUNCTION; v. 1362, p. 12-pg., 2015-01-01.
Abstract
The relationship between malignant B cells and macrophages has long been established. Furthermore, evolutionary studies have demonstrated that B cells from early vertebrates have both phagocytic and antibody production capabilities. In addition to their lymphoid nature, B-1 cells retain several myeloid characteristics. Various reports have demonstrated that B-1 cells can differentiate into phagocytes. However, descriptions of B-1 cells as a novel phagocyte cell member are rarely found in the literature. This review aims to present the available data regarding B-1 cell-derived phagocytes and also discusses how their existence might be relevant to hematopoiesis and immune responses. (AU)