Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry

Author(s)

Silva Junior, P. E. ; Rezende, L. C. D. ; Gimenes, Julia Possamai ; Maltarollo, Vinicius Goncalves ; Dale, James ; Trossini, G. H. G. ; Emery, F. S. ; Ganesan, A.

• Document type: Journal article
• Source: RSC ADVANCES; v. 6, n. 27, p. 4-pg., 2016-01-01.

Abstract

In a computational study, the 1H-pyrazolo[3,4-c]pyridin-5-ol and 2,6-naphthyridin-3-ol heterocycles were identified as unknown heteroaromatic ring systems of potential value for medicinal chemistry. Here we report robust and concise synthetic protocols that provide access to these two scaffolds on a multigram scale. (AU)

• FAPESP's process: 11/23342-9 - Synthesis, characterization and applications of BODIPY fluorophores.
• Grantee: Lucas Cunha Dias de Rezende
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 13/26485-0 - Development of new ligands for Peroxisome Proliferator-Activated Receptor by an approach of fragment based drug discovery
• Grantee: Paulo Eliandro da Silva Júnior
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 12/20990-2 - Antiinfective compounds: an evolution in the medicinal chemistry of leishmanicidal tiazoles and the search for new tuberculostic agents
• Grantee: Flavio da Silva Emery
• Support Opportunities: Regular Research Grants