| Full text | |
| Author(s): |
Kalansuriya, Pabasara
;
Quezada, Michelle
;
Esposito, Breno P.
;
Capon, Robert J.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | Journal of Natural Products; v. 80, n. 3, p. 7-pg., 2017-03-01. |
| Abstract | |
Chemical analysis of an Australian mud dauber wasp-associated fungus, Talaromyces sp. (CMB-W045), yielded five new coprogen siderophores, talarazines A-E (1-5), together with dimerumic acid (6), desferricoprogen (7), and elutherazine B (8). Structures inclusive of absolute configuration were assigned on the basis of detailed spectroscopic analysis and application of the C3 Marfey's method. We report on the noncytotoxic Fe(III) chelation properties of 1-8 and demonstrate that biosynthesis is regulated by available Fe(III) in culture media. We demonstrate a magnetic nanoparticule approach to extracting high-affinity Fe(III) binding metabolites (i.e., 8) from complex extracts. (AU) | |
| FAPESP's process: | 13/13166-4 - Bioprospection of marine siderophores aiming to iron overload chelation therapy |
| Grantee: | Breno Pannia Esposito |
| Support Opportunities: | Scholarships abroad - Research |