Diabetes Mellitus and Liver Surgery: The Effect of Diabetes on Oxidative Stress and Inflammation

Author(s)

Mendes-Braz, Mariana ; Martins, Joilson O.

• Document type: Journal article
• Source: Mediators of Inflammation; v. 2018, p. 11-pg., 2018-01-01.

Abstract

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycaemia and high morbidity worldwide. The detrimental effects of hyperglycaemia include an increase in the oxidative stress (OS) response and an enhanced inflammatory response. DM compromises the ability of the liver to regenerate and is particularly associated with poor prognosis after ischaemia-reperfusion (I/R) injury. Considering the growing need for knowledge of the impact of DM on the liver following a surgical procedure, this review aims to present recent publications addressing the effects of DM (hyperglycaemia) on OS and the inflammatory process, which play an essential role in I/R injury and impaired hepatic regeneration after liver surgery. (AU)

• FAPESP's process: 17/11540-7 - Investigating the role of insulin in the presence of allergic pulmonary inflammation in diabetic and healthy mice
• Grantee: Joilson de Oliveira Martins
• Support Opportunities: Regular Research Grants
• FAPESP's process: 16/24992-0 - Investigating the role of fibroblast growth factor 21 (FGF21) as an autophagic inducer during injury and regeneration following hepatic resection associated with ischemia-reperfusion in diabetic and healthy mice.
• Grantee: Mariana Mendes Braz
• Support Opportunities: Scholarships in Brazil - Post-Doctoral