Role of Histamine in Modulating the Immune Response and Inflammation

Author(s)

Calvielli Castelo Branco, Anna Claudia ; Yamada Yoshikawa, Fabio Seiti ; Pietrobon, Anna Julia ; Sato, Maria Notomi

• Document type: Journal article
• Source: Mediators of Inflammation; v. 2018, p. 10-pg., 2018-01-01.

Abstract

Inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, and leukotrienes, impact the immune system, usually as proinflammatory factors. Other mediators act as regulatory components to establish homeostasis after injury or prevent the inflammatory process. Histamine, a biogenic vasoactive amine, causes symptoms such as allergies and has a pleiotropic effect that is dependent on its interaction with its four histamine receptors. In this review, we discuss the dualistic effects of histamine: how histamine affects inflammation of the immune system through the activation of intracellular pathways that induce the production of inflammatory mediators and cytokines in different immune cells and how histamine exerts regulatory functions in innate and adaptive immune responses. We also evaluate the interactions between these effects. (AU)

• FAPESP's process: 12/16524-6 - Effect of histamine on the activation of dendritic cells and CD4+T cells mediated by the agonists of toll-like receptors in the newborn
• Grantee: Maria Notomi Sato
• Support Opportunities: Regular Research Grants