| Full text | |
| Author(s): |
de Jesus, J. H. F.
;
Souza, M. S.
;
Ellena, J. A.
;
Cavalheiro, E. T. G.
Total Authors: 4
|
| Document type: | Journal article |
| Source: | Thermochimica Acta; v. 680, p. 7-pg., 2019-10-01. |
| Abstract | |
Interaction of nucleotides and metals has been largely studied since they have biological importance. Divalent complexes of inosine 5'-monophosphate with cobalt(II) (IMP-Co), nickel(11) (IMP-Ni), copper(II) (IMP-Cu) and cadmium(II) (IMP-Cd) have been characterized by elemental analysis and submitted to thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC) and thermogravimetry coupled to infrared spectroscopy (TG-FTIR). Cadmium(II) complex with inosine 5'-monophosphate had also its crystalline structure elucidated by single-crystal X-ray diffraction. Elemental analysis revealed that the isolated metal complexes presented a 1:1 stoichiometry. The thermal stability order was: IMP-Co (193 degrees C) = IMP-Cd (193 degrees C) < IMP-Ni (206 degrees C) < IMP-Cu (219 degrees C), after dehydration. Cd2+ ions present octahedral coordination with an IMP ligand through nitrogen donor atom and the remaining coordinating sites through five water molecules. The crystal packing assembly has a similar distribution to the DNA molecule, with alternation between the atoms leading to a helical conformation. (AU) | |
| FAPESP's process: | 15/09299-4 - Thermal analysis applied to drugs: antidepressants |
| Grantee: | Éder Tadeu Gomes Cavalheiro |
| Support Opportunities: | Regular Research Grants |