Epigenetic alterations in salivary gland tumors

Author(s)

dos Santos, Erison S. ; Ramos, Joab C. ; Normando, Ana Gabriela C. ; Mariano, Fernanda, V ; Paes Leme, Adriana F.

• Document type: Journal article
• Source: ORAL DISEASES; v. 26, n. 8, p. 9-pg., 2020-01-22.

Abstract

Salivary gland tumors (SGTs) comprise a heterogeneous group of benign and malignant neoplasms that exhibit significant variability in their microscopic appearance, clinical presentation, and biological behavior. The etiologic factors are unknown; however, chromosomic translocation, secondary radiation, and chemotherapy can be associated with the development of SGT. It has been indicated that epigenetic alterations can be responsible for the development and progress of these neoplasms. The epigenetic mechanisms are defined as a set of DNA changes that do not alter the sequence of nucleotide bases but alter the expression of the proteins. These alterations have been studied in the SGT, and they were associated with the development and progress of these neoplasms and may influence on SGT prognosis. Hence, we critically review the currently available data on the participation of epigenetic events on salivary gland tumors. (AU)

• FAPESP's process: 15/07304-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
• Grantee: Fernanda Viviane Mariano Brum Corrêa
• Support Opportunities: Research Grants - Young Investigators Grants
• FAPESP's process: 17/00831-0 - Study of genetic and metabolic changes of pleomorphic adenoma and carcinoma ex pleomorphic adenoma by exome, gene expression and immunohistochemistry
• Grantee: Fernanda Viviane Mariano Brum Corrêa
• Support Opportunities: Scholarships in Brazil - Young Researchers
• FAPESP's process: 18/19922-9 - Proteomic analysis of tears in patients with oral potentially malignant lesions and oral squamous cell carcinoma
• Grantee: Erison Santana dos Santos
• Support Opportunities: Scholarships in Brazil - Master