| Full text | |
| Author(s): |
Giavina-Bianchi, Mara Huffenbaecher
;
Festa-Neto, Cyro
;
Sanches, Jose Antonio
;
Teixeira, Monica La Porte
;
Waldvogel, Bernadette Cunha
Total Authors: 5
|
| Document type: | Journal article |
| Source: | ANAIS BRASILEIROS DE DERMATOLOGIA; v. 95, n. 2, p. 7-pg., 2020-03-01. |
| Abstract | |
Background: The incidence and mortality of melanoma is increasing in many countries, including Brazil. Survival studies are still scarce in our country, but much needed to know and address this problem better. Objective: To analyze the disease-specific survival of patients with invasive melanoma and to correlate it with clinical and histopathological variables. Methods: Retrospective cohort analysis of 565 cases of invasive melanoma in a tertiary hospital with the objective of testing variables that could be associated with a worse prognosis, such as gender, phototype, thickness, histological type and presence of pre-existing clinical lesion at the site of the tumor. Results: The worst survival rates were significantly associated with thicker tumors (p < 0.001), male sex (p =0.014), high phototype (p = 0.047), nodular melanoma (p =0.024) and "de novo" lesions (p=0.005). When all variables were adjusted for melanoma thickness, male patients (p =0.011) and "de novo" melanomas (p =0.025) remained associated with worse survival. Study limitations: Retrospective study of a single tertiary hospital. Conclusions: Although the causes are still unknown, melanoma-specific survival was statistically worse for males and for "de novo" melanomas even after adjustment of tumor thickness. (C) 2020 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U. (AU) | |
| FAPESP's process: | 17/20928-9 - PD-L1 expression analyzes in Cutaneous Melanoma |
| Grantee: | Mara Huffenbaecher Giavina-Bianchi |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |