Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment

Author(s)

Guisier, Florian ; Barros-Filho, Mateus Camargo ; Rock, Leigha D. ; Strachan-Whaley, Megan ; Marshall, Erin A. ; Dellaire, Graham ; Lam, Wan L. ; Birbrair, A

• Document type: Journal article
• Source: TUMOR MICROENVIRONMENT: HEMATOPOIETIC CELLS, PT A; v. 1224, p. 17-pg., 2020-01-01.

Abstract

CD4+ T helper (T-H) cells are key regulators in the tumour immune microenvironment (TIME), mediating the adaptive immunological response towards cancer, mainly through the activation of cytotoxic CD8+ T cells. After antigen recognition and proper co-stimulation, naive T-H cells are activated, undergo clonal expansion, and release cytokines that will define the differentiation of a specific effector T-H cell subtype. These different subtypes have different functions, which can mediate both anti- and pro-tumour immunological responses. Here, we present the dual role of T-H cells restraining or promoting the tumour, the factors controlling their homing and differentiation in the TIME, their influence on immunotherapy, and their use as prognostic indicators. (AU)

• FAPESP's process: 18/06138-8 - Small non-coding RNA as master regulators in thyroid cancer
• Grantee: Mateus de Camargo Barros Filho
• Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
• FAPESP's process: 15/17707-5 - Development of molecular procedures useful for differential diagnosis in thyroid nodules
• Grantee: Mateus de Camargo Barros Filho
• Support Opportunities: Scholarships in Brazil - Post-Doctoral