Dataset on sociability, cognitive function, gene and protein expression of molecules involved in social behavior, reward system and synapse function following early-life status epilepticus in Wistar rats

Author(s):Show less -

Pacifico, Ana Miria ; Batista, Samuel P. ; Ribeiro, Fernanda T. ; Santos, Pedro B. dos ; Silveira, Gabriel Bruno ; Nascimento, Bruna Pascarelli Pedrico do ; Dias Junior, Eduardo ; Barbosa, Geraldo Henrique L. ; Ribeiro, Miriam Oliveira ; Silva, Sergio Gomes da ; Cysneiros, Roberta M.

• Document type: Journal article
• Source: DATA IN BRIEF; v. 31, p. 9-pg., 2020-08-01.

Abstract

Early-life status epilepticus produces deficit in social interaction and vocalization, enhances anxiety, no cognitive impairment and alters functional connectivity within the hippocampus (CA3-CA1) and between the hippocampus and prefrontal cortex [1-12], but the underlying mechanisms remain unknown. This data article contains behavioral and molecular data of the adult male Wistar rats subjected to early life pilocarpine-induced seizures. Animal's behaviors were assessed to social memory and social motivation, working and reference memories and cognitive flexibility. The brain tissues (hypothalamus, hippocampus, amygdala, and striatum) were probed to gene and protein expression of molecules related to social behavior, reward system and synaptic function. (c) 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license. (http://creativecommons.org/licenses/by/4.0/) (AU)

• FAPESP's process: 16/01154-0 - Validation of the model of neonatal status epilepticus for study of neurodevelopmental disorders
• Grantee: Roberta Monterazzo Cysneiros
• Support Opportunities: Regular Research Grants