Physical Exercise and Tumor Energy Metabolism

Author(s)

Vulczak, Anderson ; Alberici, Luciane Carla

• Document type: Journal article
• Source: CANCER TREATMENT AND RESEARCH COMMUNICATIONS; v. 32, p. 5-pg., 2022-01-01.

Abstract

Evidence supports the antitumoral effects of physical activity, either in experimental animal models or humans. However, the biological mechanisms by which physical exercise modulates tumoral development are still unclear. An important feature of the tumor cells is the altered energy metabolism, often associated with definitions of tumor aggressiveness. Nevertheless, exercise can cause global metabolic changes in the body, as well as modulate tumor metabolism. Here we specifically discuss the metabolic changes found in tumors and how exercise can contribute to anti-tumoral effects by modulating the mitochondrial function, and tricarboxylic acid cycle-related metabolites of cancer cells. The effect of physical exercise on tumor metabolism is a new possibility for comprehension of cancer biology and developing therapies focused on tumor energy metabolism. (AU)

• FAPESP's process: 16/23509-4 - Identification of neuroprotective myokines released by human skeletal muscle at low and high intensity contractions: role of mitochondrial bioenergetics and oxidative stress
• Grantee: Luciane Carla Alberici
• Support Opportunities: Regular Research Grants
• FAPESP's process: 18/10089-2 - Neural, hormonal and nutritional control of autophagy
• Grantee: Isis Do Carmo Kettelhut
• Support Opportunities: Research Projects - Thematic Grants