Imaging neuroinflammation in individuals with substance use disorders

Author(s)

Li, Xinyi ; Ramos-Rolon, Astrid P. ; Kass, Gabriel ; Pereira-Rufino, Lais S. ; Shifman, Naomi ; Shi, Zhenhao ; Volkow, Nora D. ; Wiers, Corinde E.

• Document type: Journal article
• Source: Journal of Clinical Investigation; v. 134, n. 11, p. 16-pg., 2024-06-03.

Abstract

Increasing evidence suggests a role of neuroinflammation in substance use disorders (SUDs). This Review presents findings from neuroimaging studies assessing brain markers of inflammation in vivo in individuals with SUDs. Most studies investigated the translocator protein 18 kDa (TSPO) using PET; neuroimmune markers myo-inositol, choline-containing compounds, and N -acetyl aspartate using magnetic resonance spectroscopy; and fractional anisotropy using MRI. Study findings have contributed to a greater understanding of neuroimmune function in the pathophysiology of SUDs, including its temporal dynamics (i.e., acute versus chronic substance use) and new targets for SUD treatment. (AU)

• FAPESP's process: 21/13092-7 - METHYLATION PATTERN ANALYSIS AND MORPHOFUNCTIONAL ALTERATIONS IN DECISION MAKING CONTROL NEURAL NETWORKS IN INDIVIDUALS WITH ALCOHOL USE DISORDERS
• Grantee: Laís da Silva Pereira Rufino
• Support Opportunities: Scholarships in Brazil - Post-Doctoral