Plasma ADAM10 Levels and their Association with Alzheimer's Disease Diagnosis in Older Adults with Fewer Years of Formal Education

Author(s)

Pelegrini, Lucas Nogueira de Carvalho ; da Silva, Vanessa Alexandre ; Grigoli, Marina Mantellato ; Vatanabe, Izabela Pereira ; Manzine, Patricia Regina ; Cominetti, Marcia Regina

• Document type: Journal article
• Source: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS; v. 53, n. 3, p. 9-pg., 2024-04-06.

Abstract

Introduction: Low educational attainment is a potential risk factor for Alzheimer's disease (AD) development. Alpha-secretase ADAM10 plays a central role in AD pathology, attenuating the formation of beta-amyloid peptides and, therefore, their aggregation into senile plaques. This study seeks to investigate ADAM10 as a blood-based biomarker in mild cognitive impairment (MCI) and AD in a diverse group of community-dwelling older adults, focusing on those with limited educational attainment. Methods: Participants were recruited from public health services. Cognition was evaluated using MMSE and ACE-R batteries. Blood samples were collected to analyze plasma ADAM10 levels. A logistic regression was conducted to verify the influence of plasma ADAM10 on the AD diagnosis. Results: Significant differences in age, years of education, prescribed medications, and cognitive test scores were found between the MCI and AD groups. Regarding cognitive performance, both ACE-R and MMSE scores displayed significant differences between groups, with post-hoc analyses highlighting these distinctions, particularly between AD and cognitively healthy individuals. Elevated plasma ADAM10 levels were associated with a 4.5-fold increase in the likelihood of a diagnosis of MCI and a 5.9-fold increase in the likelihood of a diagnosis of AD. These findings suggest that ADAM10 levels in plasma serve as a valuable biomarker for assessing cognitive status in older individuals with low education attainment. Conclusion: This study underscores the potential utility of plasma ADAM10 levels as a blood-based biomarker for cognitive status, especially in individuals with low educational backgrounds, shedding light on their relevance in AD development and diagnosis. (AU)

• FAPESP's process: 23/08952-2 - Training and technical training for the project 'Biology and function of ADAM10 isoforms for the differential diagnosis of Alzheimer's disease through electrochemical sensors'
• Grantee: Marina Mantellatto Grigoli
• Support Opportunities: Scholarships in Brazil - Technical Training Program - Technical Training
• FAPESP's process: 22/15314-0 - Effects of single nucleotide polymorphisms (SNPs) on ADAM10 levels and activities in patients with dementia of Alzheimer's disease compared to cognitively healthy older adults
• Grantee: Lucas Pelegrini Nogueira de Carvalho
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 21/01863-9 - Biology and function of ADAM10 isoforms for differential diagnosis of Alzheimer's Disease by electrochemical sensors
• Grantee: Márcia Regina Cominetti
• Support Opportunities: Research Projects - Thematic Grants