Fractional Tumour-Immune Model with Drug Resistance

Author(s)

Koltun, Ana P. S. ; Trobia, Jose ; Batista, Antonio M. ; Lenzi, Ervin K. ; Santos, Moises S. ; Borges, Fernando S. ; Iarosz, Kelly C. ; Caldas, Ibere L. ; Gabrick, Enrique C.

• Document type: Journal article
• Source: Brazilian Journal of Physics; v. 54, n. 2, p. 6-pg., 2024-04-01.

Abstract

Cancer is a group of diseases in which cells grow uncontrollably and can spread into other tissues. Various studies consider the interactions between cancer cells and the immune system as well as different types of treatment. Mathematical models have been used to study the growth of cancerous cells. We study a fractional order model that describes some aspects of the interactions among host, effector immune, and cancer cells. A drug treatment is considered to analyse the cancerous cells proliferation. Due to the chemotherapy, we split the fractional equation of the cancerous cells into drug sensitivity and resistance. We show that not only the chemotherapy but also the drug resistance plays an important role in the growth rate of cancer cells. (AU)

• FAPESP's process: 18/03211-6 - Non linear dynamics
• Grantee: Iberê Luiz Caldas
• Support Opportunities: Research Projects - Thematic Grants