| Full text | |
| Author(s): |
Gantner, Benjamin N.
;
Palma, Flavio R.
;
Kayzuka, Cezar
;
Lacchini, Riccardo
;
Foltz, Daniel R.
;
Backman, Vadim
;
Kelleher, Neil
;
Shilatifard, Ali
;
Bonini, Marcelo G.
Total Authors: 9
|
| Document type: | Journal article |
| Source: | TRENDS IN GENETICS; v. 40, n. 9, p. 8-pg., 2024-09-09. |
| Abstract | |
The emergence of aerobic respiration created unprecedented bioenergetic advantages, while imposing the need to protect critical genetic information from reactive byproducts of oxidative metabolism (i.e., reactive oxygen species, ROS). The evolution of histone proteins fulfilled the need to shield DNA from these potentially damaging toxins, while providing the means to compact and structure massive eukaryotic genomes. To date, several metabolism-linked histone post-translational modifications (PTMs) have been shown to regulate chromatin structure and gene expression. However, whether and how PTMs enacted by metabolically produced ROS regulate adaptive chromatin remodeling remain relatively unexplored. Here, we review novel mechanistic insights into the interactions of ROS with histones and their consequences for the control of gene expression regulation, cellular plasticity, and behavior. (AU) | |
| FAPESP's process: | 20/11740-9 - Evaluation of epigenetic mechanisms in response to drug treatments in genes related to Hypertension in an experimental animal model |
| Grantee: | Cezar Kayzuka Cotta Filho |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 22/07921-3 - Aging-associated Pulmonary Vascular Injury via NOS1/3-mediated oxidative stress |
| Grantee: | Cezar Kayzuka Cotta Filho |
| Support Opportunities: | Scholarships abroad - Research Internship - Doctorate (Direct) |