| Full text | |
| Author(s): |
Donato, Jose, Jr.
Total Authors: 1
|
| Document type: | Journal article |
| Source: | NATURE REVIEWS ENDOCRINOLOGY; v. 19, n. 7, p. 13-pg., 2023-07-01. |
| Abstract | |
The intrauterine and early postnatal periods represent key developmental stages in which an organism is highly susceptible to being permanently influenced by maternal factors and nutritional status. Strong evidence indicates that either undernutrition or overnutrition during development can predispose individuals to disease later in life, especially type 2 diabetes mellitus and obesity, a concept known as metabolic programming. Adipose tissue produces important signalling molecules that control energy and glucose homeostasis, including leptin and adiponectin. In addition to their well-characterized metabolic effects in adults, adipokines have been associated with metabolic programming by affecting different aspects of development. Therefore, alterations in the secretion or signalling of adipokines, caused by nutritional insults in early life, might lead to metabolic diseases in adulthood. This Review summarizes and discusses the potential role of several adipokines in inducing metabolic programming through their effects during development. The identification of the endocrine factors that act in early life to permanently influence metabolism represents a key step in understanding the mechanisms behind metabolic programming. Thus, future strategies aiming to prevent and treat these metabolic diseases can be designed, taking into consideration the relationship between adipokines and the developmental origins of health and disease. (AU) | |
| FAPESP's process: | 20/01318-8 - Central nervous system as a target of growth hormone for the regulation of multiple biological functions |
| Grantee: | Jose Donato Junior |
| Support Opportunities: | Research Projects - Thematic Grants |