Methods for extraction, isolation and sequencing of cyclotides and others cyclic peptides with anti-helminthic activities: An overview

Author(s)

Eteme, Olivier Ndogo ; Zondegoumba, Ernestine Nkwengoua ; Tadayozzi, Yasmin Saegusa ; Serafim, Jessica Aparecida ; Leite, Wendell Queiroz ; Severino, Mariane de Freitas Genari ; Vicente, Eduardo Festozo

• Document type: Journal article
• Source: Parasitology International; v. 98, p. 10-pg., 2023-10-04.

Abstract

The mortality rate caused by parasitic worms on their hosts is of great concern and studies have been carried out to find molecules to reduce the prevalence, host-parasite interaction, and resistance of parasites to treatments. Existing drugs on the market are very often toxic and have many side effects, hence the need to find new, more active molecules. It has been demonstrated in several works that medicinal plants constitute a wide range of new molecules that can solve this problem. Several works have already been able to demonstrate that cyclic peptides of plant origin have shown good activity in the fight against different types of helminths. Therefore, this review aims to provide a general overview of the methods and techniques of extraction, isolation, activities and mechanisms of action of cyclotides and other cyclic peptides for application in the treatment of helminthic infections. (AU)

• FAPESP's process: 21/06706-9 - Antimicrobial peptides: expanding the horizons for animal production performance optimization
• Grantee: Eduardo Festozo Vicente
• Support Opportunities: Research Grants - Young Investigators Grants - Phase 2
• FAPESP's process: 22/02808-4 - Evaluation of protease inhibitory properties and biological activities from Allexis cauliflora's cyclotides for application in animal nutrition
• Grantee: Ndogo Eteme Olivier
• Support Opportunities: Scholarships in Brazil - Post-Doctoral