| Full text | |
| Author(s): Show less - |
Chagas, Pablo Shimaoka
;
Garcia, Cristiana Bernadelli
;
Sousa, Lucas Oliveira
;
da Silva, Gabriel
;
de Sousa, Graziella Ribeiro
;
Marcelino, Rodolfo Cabral
;
de Matos, Leandro Luongo
;
Kowalski, Luiz Paulo
;
Salles, Evila
;
Wang, Lei
;
Baban, Babak
;
Leopoldino, Andreia Machado
Total Authors: 12
|
| Document type: | Journal article |
| Source: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 25, n. 22, p. 13-pg., 2024-11-01. |
| Abstract | |
Emerging evidence suggests that aberrant expression levels of Sigma1 (SIGMAR1, also known as sigma-1 receptor) have been implicated in the progression of various diseases, including cancer. However, its significance in oral cancer (OC) has not been thoroughly explored. To advance in this field, the present study aimed to investigate the impact of SIGMAR1 knockdown in oral cancer cells. To do so, we included in this study our cohort of human OC samples and OC cell lines, which were utilized for experimental verification through several in vitro assays. Our findings revealed that SIGMAR1 overexpression was associated with poor survival rates and positively correlated with PD-L1 overexpression in human oral cancer samples. Furthermore, SIGMAR1 inhibition led to a decrease in PD-L1 expression and sensitized oral cancer cells to cisplatin treatment by enhancing apoptosis. These results suggest that SIGMAR1 knockdown may present a promising strategy worthy of further exploration in the management of oral cancer. (AU) | |
| FAPESP's process: | 21/03732-9 - Characterization of Sig-1R in the immune and metabolic response of sphingolipids as a chemoresistant factor in oral cavity cancer |
| Grantee: | Pablo Shimaoka Chagas |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 22/07821-9 - Establishment of a Zebrafish model to study the role of SIGMAR1 in oral cancer-immunity cycle |
| Grantee: | Pablo Shimaoka Chagas |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 16/19103-2 - SET and sphingolipids in head and neck squamous cell carcinoma: signaling, targets and antiumoral therapy |
| Grantee: | Andréia Machado Leopoldino |
| Support Opportunities: | Research Projects - Thematic Grants |