Graph network and symmetry analysis after combined XR and tDCS in stroke

Author(s):Show less -

Carlos, Bruna M. ; Menezes, Lucas T. ; Rosa, Beatriz ; Furumoto, Bruna F. ; Feitosa, Saulo S. ; Fernandes, Corina A. ; Ferreira-Melo, Silvia E. ; Pereira, Julia D. ; Almeida, Sara ; Brandao, Alexandre F. ; Ruas, Cassio V. ; Castellano, Gabriela

• Document type: Journal article
• Source: Biomedical Signal Processing and Control; v. 96, p. 9-pg., 2024-06-05.

Abstract

The integration of innovative neurotechnologies in rehabilitation programs seems promising for enhancing motor recovery in people with stroke. This study presents a comprehensive exploration of brain connectivity with symmetry and graph network analyses during motor rehabilitation using extended reality (XR) training and transcranial direct current stimulation (tDCS). The evolution of selected electroencephalography (EEG) features was assessed along with changes in clinical scores before and after the rehabilitation program in order to identify directions for future research. Clinical motor performance scales and resting -state EEG assessments showed trends indicating the improvement of connectivity and integration capacity over rehabilitation time, particularly within the theta, beta, and gamma frequency bands. Symmetry indices, particularly at higher frequencies, were significantly correlated with clinical improvements, demonstrating a stronger relationship between brain symmetry and lower extremity function as well as an increasing symmetry trend at the end of the rehabilitation program. Based upon the preliminary findings of this study, rehabilitation sessions that combine XR and tDCS can induce changes in neuroplasticity and improve motor recovery, which may in turn increase the life quality of people with stroke. (AU)

• FAPESP's process: 15/03695-5 - Application and development of virtual reality tools to complement conventional therapy of stroke patients and evaluation of recovery using brain connectivity through fMRI
• Grantee: Alexandre Fonseca Brandão
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
• Grantee: Fernando Cendes
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 20/16571-0 - Investigation of brain changes in neurological patients undergoing different rehabilitation treatments
• Grantee: Bruna Mezzari Carlos
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 22/08057-0 - Neuromodulation combined with other neurotechnologies for application in the motor rehabilitation of Stroke patients
• Grantee: Cássio Víctora Ruas
• Support Opportunities: Scholarships in Brazil - Post-Doctoral