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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Endothelial Nitric Oxide Synthase Polymorphisms and Adaptation of Parasympathetic Modulation to Exercise Training

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Silva, Bruno M. [1, 2, 3] ; Neves, Fabricia J. [1, 2] ; Negrao, Marcelo V. [4] ; Alves, Cleber R. [4] ; Dias, Rodrigo G. [4] ; Alves, Guilherme B. [4] ; Pereira, Alexandre C. [4] ; Rondon, Maria U. [4] ; Krieger, Jose E. [4] ; Negrao, Carlos E. [4, 5] ; Lucas da Nobrega, Antonio Claudio [1, 2, 3]
Total Authors: 11
[1] Univ Fed Fluminense, Dept Physiol & Pharmacol, Niteroi, RJ - Brazil
[2] Univ Fed Fluminense, Grad Program Cardiovasc Sci, Niteroi, RJ - Brazil
[3] Univ Estado Rio De Janeiro, Grad Program Clin & Expt Pathophysiol, Rio De Janeiro - Brazil
[4] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Phys Educ & Sport, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: MEDICINE AND SCIENCE IN SPORTS AND EXERCISE; v. 43, n. 9, p. 1611-1618, SEP 2011.
Web of Science Citations: 9

SILVA, B. M., F. J. NEVES, M. V. NEGRAO, C. R. ALVES, R. G. DIAS, G. B. ALVES, A. C. PEREIRA, M. U. RONDON, J. E. KRIEGER, C. E. NEGRAO, and A. C. DA NOBREGA. Endothelial Nitric Oxide Synthase Polymorphisms and Adaptation of Parasympathetic Modulation to Exercise Training. Med. Sci. Sports Exerc., Vol. 43, No. 9, pp. 1611-1618, 2011. Purpose: There is a large interindividual variation in the parasympathetic adaptation induced by aerobic exercise training, which may be partially attributed to genetic polymorphisms. Therefore, we investigated the association among three polymorphisms in the endothelial nitric oxide gene (-786T>C, 4b4a, and 894G>T), analyzed individually and as haplotypes, and the parasympathetic adaptation induced by exercise training. Methods: Eighty healthy males, age 20-35 yr, were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis, and haplotypes were inferred using the software PHASE 2.1. Autonomic modulation (i.e., HR variability and spontaneous baroreflex sensitivity) and peak oxygen consumption ((V) over dotO(2peak)) were measured before and after training (running, moderate to severe intensity, three times per week, 60, during 18 wk). Results: Training increased (V) over dotO(2peak) (P < 0.05) and decreased mean arterial pressure (P < 0.05) in the whole sample. Subjects with the -786C polymorphic allele had a significant reduction in baroreflex sensitivity after training (change: wild type (-786TT) = 2% +/- 89% vs polymorphic (-786TC/CC) = -28% +/- 60%, median +/- quartile range, P = 0.03), and parasympathetic modulation was marginally reduced in subjects with the 894T polymorphic allele (change: wild type (894GG) = 8% +/- 67% vs polymorphic (894GT/TT) = -18% +/- 59%, median +/- quartile range, P = 0.06). Furthermore, parasympathetic modulation percent change was different between the haplotypes containing wild-type alleles(-786T/4b/894G) and polymorphic alleles at positions -786 and 894 (-786C/4b/894T) (-6% +/- 56% vs -41% +/- 50%, median T quartile range, P = 0.04). Conclusions: The polymorphic allele at position -786 and the haplotype containing polymorphic alleles at positions -786 and 894 in the endothelial nitric oxide gene were associated with decreased parasympathetic modulation after exercise training. (AU)

FAPESP's process: 05/59740-7 - Physical exercise and autonomic control in cardiovascular physiopathology
Grantee:Carlos Eduardo Negrão
Support type: Research Projects - Thematic Grants