| Full text | |
| Author(s): |
Reis, Thamara Goncalves
;
Del Colletto, Alice Marcela Sampaio
;
Silva, Luiz Augusto Santana
;
Koga, Bruna Andrade Aguiar
;
Sogayar, Mari Cleide
;
Carreira, Ana Claudia Oliveira
Total Authors: 6
|
| Document type: | Journal article |
| Source: | BIOMOLECULES; v. 14, n. 3, p. 19-pg., 2024-03-01. |
| Abstract | |
Bone morphogenetic protein (BMP) and platelet-derived growth factor (PDGF) are known to regulate/stimulate osteogenesis, playing vital roles in bone homeostasis, rendering them strong candidates for osteoporosis treatment. We evaluated the effects of recombinant human BMP-7 (rhBMP7) and PDGF-BB (rhPDGF-BB) in an oophorectomy-induced osteoporosis rat model. Forty Sprague Dawley rats underwent oophorectomy surgery; treatments commenced on the 100th day post-surgery when all animals exhibited signs of osteoporosis. These peptide growth factors were administered intraocularly (iv) once or twice a week and the animals were monitored for a total of five weeks. Two weeks after the conclusion of the treatments, the animals were euthanized and tissues were collected for assessment of alkaline phosphatase, X-ray, micro-CT, and histology. The results indicate that the most promising treatments were 20 mu g/kg rhPDGF-BB + 30 mu g/kg rhBMP-7 twice a week and 30 mu g/kg BMP-7 twice a week, showing significant increases of 15% (p < 0.05) and 13% (p < 0.05) in bone volume fraction and 21% (p < 0.05) and 23% (p < 0.05) in trabecular number, respectively. In conclusion, rhPDGF-BB and rhBMP-7 have demonstrated the ability to increase bone volume and density in this osteoporotic animal model, establishing them as potential candidates for osteoporosis treatment. (AU) | |
| FAPESP's process: | 16/05311-2 - Regenerative medicine aiming at therapy for chronic degenerative diseases (cancer and diabetes) |
| Grantee: | Mari Cleide Sogayar |
| Support Opportunities: | Research Projects - Thematic Grants |