Imported Cutaneous Leishmaniasis from Peru Caused by Leishmania (Viannia) guyanensis in a Brazilian Patient: Case Report and In Vitro Drug Susceptibility Analysis

Author(s)

Coser, Elizabeth M. ; Aoki, Juliana I. ; Saborito, Cristiele ; de la Roca, Stephane ; Brufatto, Joao Paulo T. ; Angerami, Rodrigo ; Stelini, Rafael F. ; Velho, Paulo Eduardo N. F. ; Coelho, Adriano C.

• Document type: Journal article
• Source: TROPICAL MEDICINE AND INFECTIOUS DISEASE; v. 9, n. 11, p. 7-pg., 2024-11-01.

Abstract

In South America, cutaneous leishmaniasis is caused by several species of the parasite of the genus Leishmania. Here, we describe an imported case of cutaneous leishmaniasis acquired in Peru by a Brazilian patient during her travel to Iquitos. Infection by Leishmania parasites was confirmed by histopathologic examination, and the patient was treated with pentavalent antimony (Pentostam), without clinical response. Molecular typing was performed by sequencing the ribosomal DNA internal transcribed spacer and heat-shock protein 70 gene, which identified the parasites as Leishmania guyanensis. The clinical isolate was similarly susceptible to amphotericin B, pentamidine, and miltefosine as the reference strain, while for pentavalent antimony, this clinical isolate was more susceptible than the reference strain, even though its susceptibility in vitro was still considered low. The patient was then treated with liposomal amphotericin B, with clinical improvement of the lesions. (AU)

• FAPESP's process: 22/06176-2 - Characterization of a Leishmania amazonensis clinical isolate multiresistant to the drugs used in the treatment of leishmaniasis
• Grantee: Stephane Soares Gomes Senhorinha
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 19/22175-3 - Identification and functional validation of genes associated with susceptibility and resistance to paromomycin in Leishmania spp
• Grantee: Elizabeth Magiolo Coser
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/00171-6 - Functional characterization of a phospholipid transporter of Leishmania braziliensis: possible role in susceptibility to miltefosine
• Grantee: Cristiele Saborito da Silva
• Support Opportunities: Scholarships in Brazil - Master
• FAPESP's process: 16/21171-6 - Paromomycin for the treatment of Tegumentary Leishmaniasis: investigation in vitro, in vivo and in the identification of molecular markers associated with susceptibility and resistance
• Grantee: Adriano Cappellazzo Coelho
• Support Opportunities: Research Grants - Young Investigators Grants