| Full text | |
| Author(s): |
Oliveira, Mariana de Araujo
;
de Almeida, Sandro Rogerio
;
Martins, Joilson O.
Total Authors: 3
|
| Document type: | Journal article |
| Source: | JOURNAL OF FUNGI; v. 10, n. 8, p. 14-pg., 2024-08-01. |
| Abstract | |
Sporotrichosis is a type of zoonotic subcutaneous mycosis caused by different species of dimorphic fungus of the genus Sporothrix, and it is the most common form of subcutaneous mycosis in Latin America. Sporotrichosis is generally restricted to cutaneous and lymphatic tissue (i.e., localized forms), and involvement in the viscera (i.e., disseminated or disseminated cutaneous form) is uncommon, especially in the central nervous system. However, immunosuppression in individuals with diabetes mellitus can lead to the disseminated form of the disease due to a failure to eliminate the pathogen and poor infection treatment outcomes. Possible correlations between patients with diabetes and their greater susceptibility to disseminated cases of sporotrichosis include a decreased cytokine response after stimulation, increased oxidative stress, decreased chemotaxis, phagocytic activity, adhesion and rolling of neutrophils and monocytes/macrophages, and increased macrophage/monocyte and polymorphonuclear cell apoptosis. Therefore, this review highlights novel insights into diabetes and sporotrichosis by investigating how chronic inflammation affects and aggravates the infection, the possible causes of the greater susceptibility of Sporothrix sp. to hematogenous dissemination in immunocompromised patients, and the main alterations that this dissemination can cause. (AU) | |
| FAPESP's process: | 24/00810-7 - Investigating autophagic mechanisms in the presence of subcutaneous mycosis caused by Sporotrhix brasiliensis in diabetic animals |
| Grantee: | Joilson de Oliveira Martins |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 22/07100-0 - Evaluation of the autophagic process in macrophages and lymphocytes in systemic mycoses caused by Paracoccidioides brasiliensis in healthy and diabetic animals |
| Grantee: | Mariana de Araujo Oliveira |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 22/00482-4 - Investigating autophagic mechanisms in mice with accelerated senescence |
| Grantee: | Joilson de Oliveira Martins |
| Support Opportunities: | Regular Research Grants |