| Full text | |
| Author(s): Show less - |
Nunes, Ana Carolina Vasconcelos
;
Trevisan, Camila Martins
;
Peluso, Carla
;
Loureiro, Flavia Althman
;
Dias, Alexandre Torchio
;
Rincon, Daniel
;
Fonseca, Fernando Luiz Affonso
;
Christofolini, Denise Maria
;
Lagana, Antonio Simone
;
Montagna, Erik
;
Barbosa, Caio Parente
;
Bianco, Bianca
Total Authors: 12
|
| Document type: | Journal article |
| Source: | DNA AND CELL BIOLOGY; v. 43, n. 8, p. 11-pg., 2024-06-18. |
| Abstract | |
Dynamic mutations in the 5 ' untranslated region of FMR1 are associated with infertility. Premutation alleles interfere with prenatal development and increase infertility risks. The number of CGG repeats that causes the highest decrease in ovarian reserves remains unclear. We evaluated the effect of FMR1 CGG repeat lengths on ovarian reserves and in vitro fertilization (IVF) treatment outcomes in 272 women with alleles within the normal range. FMR1 CGG repeat length was investigated via PCR and capillary electrophoresis. Alleles were classified as low-normal, normal, and high-normal. Serum levels of follicle-stimulating hormone and anti-Mullerian hormone (AMH) in the follicular phase of the menstrual cycle were measured, and antral follicles (AFC) were counted. IVF outcomes were collected from medical records. Regarding FMR1 CGG repeat length alleles, 63.2% of women presented at least one low-normal allele. Those carrying low-normal alleles had significantly lower AMH levels than women carrying normal or high-normal alleles. Low-normal/low-normal genotype was the most frequent, followed by low-normal/normal and normal/normal. A comparison of ovarian reserve markers and reproductive outcomes of the three most frequent genotypes revealed that AFC in the low-normal/normal genotype was significantly lower than the low-normal/low-normal genotype. The low number of FMR1 CGG repeats affected AMH levels and AFC but not IVF outcomes per cycle of treatment. (AU) | |
| FAPESP's process: | 20/08643-1 - The impact of CGG repeat length in the UTR 5' region of the FMR1 gene in the ovarian reserve and reproductive outcomes of women undergoing assisted reproduction |
| Grantee: | Bianca Alves Vieira Bianco |
| Support Opportunities: | Regular Research Grants |