Refining the circuits of drug addiction: The ventral pallidum

Full text
Author(s):	Morais-Silva, Gessynger ; Lobo, Mary Kay Total Authors: 2
Document type:	Journal article
Source:	CURRENT OPINION IN NEUROBIOLOGY; v. 86, p. 7-pg., 2024-05-29.
Abstract
The ventral pallidum is a prominent structure within the basal ganglia, regulating reward and motivational processes. Positioned at the interface between motor and limbic structures, its function is crucial to the development and maintenance of substance use disorders. Chronic drug use induces neuroplastic events in this structure, leading to long-term changes in VP neuronal activity and synaptic communication. Moreover, different neuronal populations within the VP drive drug-seeking behavior in opposite directions. This review explores the role of the VP as a hub for reward, motivation, and aversion, establishing it as an important contributor to the pathophysiology of substance use disorders. (AU)

FAPESP's process:	18/05496-8 - Role of the ventral pallido-accumbal projections in the susceptibility to social defeat stress
Grantee:	Gessynger Morais Silva
Support Opportunities:	Scholarships abroad - Research Internship - Doctorate


FAPESP's process:	20/15216-2 - Evaluation of the medial prefrontal cortex interhemispheric connections in the resilience and susceptibility to the social defeat stress: because the side matters
Grantee:	Gessynger Morais Silva
Support Opportunities:	Scholarships in Brazil - Post-Doctoral