Insights into incipient oral squamous cell carcinoma: a comprehensive south-american study

Author(s):Show less -

Saldivia-Siracusa, Cristina ; Araujo, Anna Luiza Damaceno ; Arboleda, Lady Paola Aristizabal ; Abrantes, Thamiris ; Pinto, Mariana Bitu Ramos ; Mendonca, Nathalia ; Cordero-Torres, Karina ; Gilligan, Gerardo ; Piemonte, Eduardo ; Panico, Rene ; De-Abreu-Alves, Fabio ; Villaroel-Dorrego, Mariana ; Romanach, Mario Jose ; Abrahao, Aline Correa ; Gonzalez-Arriagada, Wilfredo Alejandro ; Hunter, Keith ; Ribeiro, Ana Carolina Prado ; Lopes, Marcio Ajudarte ; Vargas, Pablo Agustin ; Santos-Silva, Alanroger

• Document type: Journal article
• Source: MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL; v. 29, n. 4, p. 9-pg., 2024-07-01.

Abstract

Background: To describe demographic and clinicopathological aspects of a South -American cohort of incipient oral squamous cell carcinoma patients. Material and Methods: A cross-sectional, observational study was performed to assess demographic and clinicopathological characteristics of incipient oral squamous cell carcinoma patients from 6 South -American institutions. Results: One hundred and seven patients within the histopathological spectrum of incipient oral squamous cell carcinoma (in -situ and microinvasive) were included. Fifty-eight (54.2%) patients were men with a mean age of 60.69 years. Forty-nine (45.8%) and thirty-nine (36.5%) patients had history of tobacco and alcohol use, respectively. Clinically, most of the lesions were plaques (82.2%), >= 2 cm in extension (72%), affecting the lateral border of the tongue (55.1%), and soft palate (12.1%) with a mixed (white and red) appearance. Eighty-two (76.7%) lesions were predominantly white and 25 (23.3%) predominantly red. Conclusions: To the best of our knowledge, this is the largest cohort of incipient oral squamous cell carcinoma patients, which raises awareness of clinicians' inspection acuteness by demonstrating the most frequent clinical aspects of this disease, potentially improving oral cancer secondary prevention strategies. (AU)

• FAPESP's process: 22/13069-8 - ARTIFICIAL INTELLIGENCE FOR CLINICAL AND HISTOPATHOLOGICAL DIAGNOSIS OF INCIPIENT ORAL SQUAMOUS CELL CARCINOMA: A MULTICENTRIC INTERNATIONAL STUDY
• Grantee: Cristina Saldivia Siracusa
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 21/14585-7 - Artificial intelligence applied to the clinical and histopathological diagnosis of Head and Neck Cancer
• Grantee: Anna Luiza Damaceno Araujo
• Support Opportunities: Scholarships in Brazil - Post-Doctoral